Abstract
Binding affinities for a range of epibatidine isomers and analogues at the alpha4beta2 and alpha3beta4 nAChR subtypes are reported; compounds having similar N-N distances to epibatidine show similar, high potencies.
MeSH terms
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Bridged Bicyclo Compounds, Heterocyclic / chemistry*
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Bridged Bicyclo Compounds, Heterocyclic / pharmacology*
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Cell Line
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Humans
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Isomerism
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Nicotinic Agonists / chemistry*
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Nicotinic Agonists / pharmacology*
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Pyridines / chemistry*
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Pyridines / pharmacology*
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Structure-Activity Relationship
Substances
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Bridged Bicyclo Compounds, Heterocyclic
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Nicotinic Agonists
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Pyridines
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epibatidine